--The major cardiovascular manifestation in Marfan Syndrome is a progressive dilatation of the ascending aorta, leading to aortic aneurysm formation and eventually to fatal aortic rupture or dissection. Aortic dissecti
--The ascending and descending aorta are both abnormal in Marfan Syndrome.
· The descending aorta is affected in two out of three patients during aortic dissection, and is the site of most complications which occur during follow-up.
· Aortic dissection limited to the descending aorta can occur in patients without dilatation of the ascending aorta.
--Dissection of the descending aorta was associated with dissection of ascending aorta in 43% and was isolated in 20% of cases.
BOTTOM LINE:
--dissections in Marfan involve descending aorta ~2/3 of the time, but these frequently involve the ascending aorta also
--if you have a patient with Marfan, and are worried about a dissection...worry about both (ascending/descending)
Submitted by J. Gullo.
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