--According to the study below (even though its in pigs), being on replacement enzymes shouldn't affect your lipase levels.
PMID: 14707735
--The enzyme levels in blood are not affected by oral administration of a pancreatic enzyme preparation (Creon 10,000) in pancreas-insufficient pigs.
--The current study investigated whether orally administered pancreatic enzymes were absorbed from the intestine.
--28 pigs; 3 control pigs with intact pancreatic function and 25 pigs that were made exocrine pancreas insufficient by duct ligation (20 pigs) or total pancreatectomy (5 pigs).
--pigs received a pancreatic enzyme preparation (0, 2, 4, or 8 g of Creon 10,000) together with the feed. The blood plasma was analyzed for pancreatic lipase activity.
--Administration of Creon (0–8 g) caused no significant changes in plasma (pro)colipase or cationic trypsin(ogen) levels.
BOTTOM LINE: