Tuesday, April 24, 2012

octreotide in sulfonylurea overdose

BASIC IDEA:
--Octreotide inhibits the secretion of several neuropeptides, including insulin
--if someone overdoses on a sulfonylurea (e.g. glipizide), would giving octreotide help reduce the hypoglycemia problem?


(straight to the) BOTTOM LINE:
--limited studies out there, but reviews tend to say the same thing...
--octreotide is probably safe and beneficial in sulfonylurea overdose/hypoglycemia


Reference(s): http://www.ncbi.nlm.nih.gov/pubmed/17764782 , http://www.ncbi.nlm.nih.gov/pubmed/16356235, http://www.ncbi.nlm.nih.gov/pubmed/17652687, http://www.ncbi.nlm.nih.gov/pubmed/20352540

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