Tuesday, December 20, 2011

Dexamethasone Instead of Prednisone for Acute Asthma

EMERGENCY MEDICINE NEWS:
--this month's journal had a nice breakdown of a couple articles about using dex instead of prednisone to treat asthma exacerbations. head over there for details, its a decent read


10-SECOND VERSION:
--corticosteroids (with bronchodilators) help avoid admission & ED relapse in acute asthma exacerbations
--dexamethasone has longer half-life (days) than prednisone (hours)
--dex 0.6mg/kg daily (x 2 days) vs. prednisone 1mg/kg daily (x 5 days)
--adult size: dex 16mg/day vs. pred 60mg/day
--limited studies, but generally dex was same or slightly better
--dex is probably ok alternative to pred

Reference(s): emergency medicine news: article, uptodate.com: prednisone, dexamethasone, picture

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